Royal Decree no. MB/ 5997 was issued on 10 Sha`ban, 1427 A.H. to establish the College of Health Sciences in Al-Leith. It was an addition to the group of medical colleges at Umm Al-Qura University and Dr. Ahmad bin Omar Babalgith was selected as the first dean of the college in the period from 1431 A.H. until 1433 A.H.

He was followed by Dr. Faris bin Muhammad Noor Altaf, who was appointed as the second dean of the college on 21 Rabi` I 1433 A.H.  He took over the deanship from 1433 A.H., until 1438 A.H. During his tenure, the college witnessed a giant leap. The headquarters was rented in Al-Leith, the academic and administrative staff were appointed for the first time, the college's organizational and administrative structures were developed, the curricula committee was set, the public health program was approved, and the students began to study it.

He was succeeded by His Excellency Dr. Tariq bin Abdullah Ahmad Zhafar, who has been the dean of the college since Safar 1438 A.H. until the present time. He continued the college's development march. During his tenure, the college witnessed the graduation of the first batch of students, new departments have been introduced, and new study programs at the bachelor's and master's levels have been added. He also developed the college facilities, most notably, the classrooms, laboratories, and student club.