Adham University College, represented by its dean, His Excellency Dr. Saeed Al-Bahairi, and all its affiliates, offers its sincere thanks and appreciation to her Excellency Ms. Nadia Al-Qurashi, academic staff member at the Department of Basic Sciences, for her scientific and research contributions, which are of great benefit to the department, college, and university. The college wishes her more progress and distinction.

You can find below more details about the research paper:

New azoloazine derivatives as antimicrobial agents: Synthesis under microwave irradiations, structure elucidation, and antimicrobial activity

Asmaa F. Kassem¹ | Eman M.H. Abbas¹ | Nadia T. Al-Qurashi² | Thoraya A. Farghaly^3,4*

¹Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 ElBohouth Street (former El Tahrir St.) Dokki, Giza, P.O. Box 12622, Egypt

²Department of Basic Science, University College in Adam, Umm Al-Qura University, Makkah, Almukkarramah, Saudi Arabia

³Department of Chemistry, Faculty of Science, Cairo University, Giza, 1263, Egypt

⁴Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Almukkarramah, 21514, Saudi Arabia

Abstract

With aiding of microwave radiation, new series of fused-thiazolopyrimidines and fused-triazolopyrimidines each with cycloheptane have been synthesized through the reaction of cycloheptane-thione with α-haloketones or hydrazonoyl chlorides in short-time intervals as well as high yield. Moreover, reaction of 2,7-bis(2-chlorobenzylidene)cycloheptan-1-one with o-aminothiophenol and heterocyclic amines afforded benzo[b]cyclohepta[e][1,4]thiazepine derivative and cycloheptapyrimidines fused with different azoles, respectively. The structure for all products was discussed and proved based on the results of spectral data and elemental analysis. Evaluation of the antimicrobial activity of selected products indicated that most of derivatives showed their potent activity exceeds the reference antibiotic in some cases.