Alaa A. Ghazzawi 1, Reham S. Baghdadi 2, Hamza M. Assaggaf 3, Firas S. Azzeh1*
1 Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
2 Department of Clinical Nutrition, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.
3 Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Volume: Special Issue | Pages: 38-46| April 2025| https://doi.org/10.54940/ms46329897 | PDF
Received:18/12/2024 |Accepted:23/01/2025
*Corresponding Author: fsazzeh@uqu.edu.sa
Abstract
Background/ Purpose of the research: The impressive beneficial effects of thiamine in many diseases have recently gained widespread attention. However, this study investigated the impact of administer-ing intravenous thiamineon clinical outcomes in traumatic brain injury (TBI) pa-tients admitted to ICU.
Materials/ Methods: Retrospective cohort observational design from January 2019 to Decem-ber 2020 for TBI patients admitted to ICU; Al-Noor Specialist Hospital, Makkah, was per-formed. The selected sample (221 with TBI) was grouped into a treatment group (received thiamine therapy, 100 mg/day; n=7) and a control group. Matched treatment and control groups were assigned and compared in terms of Glasgow Coma Scale (GCS) and biochemical parame-ters. All parameters were compared between both groups at hospital discharge.
Results: Thiamine administration did not achieve any significant impact between the control and treatment groups on lactate level (1.2 vs. 1.6 mmol/L; P = 0.22) or GCS progression on discharge (2.6 vs. 2.2, P = 0.578). This therapy had an impact on other biochemical outcomes including hemoglobin (78 vs. 97 g/L, P = 0.004) and blood urea nitrogen (4.8 vs. 7.6 mmol/L, P = 0.005), which were significantly higher in the treatment group, while serum sodium level was significantly lower in the treatment group (143 vs. 140 mmol/L, P = 0.013).
Conclusions: The administration of thiamine therapy had no clinical impact on lactate or GCS in patients with TBI at hospital discharge, and a significant impact was observed for hemoglo-bin, blood urea nitrogen, and sodium levels.
Keywords
hiamine, Critically ill, Trau-matic brain injury, Glasgow Coma Scale, Lactate
How to Cite
Ghazzawi, A. Baghdadi, R. Assaggaf, H. Azzeh, F. (2025). The Effect of Thiamine Administration on Clinical Outcomes in Traumatic Brain Injury Patients Saudi Arabia, Journal of Umm Al-Qura University for Medical Sciences, Special Issue, 38-46. https://doi.org/10.54940/ms46329897
License
1658-4740/© 2025-by the Authors. Published by-J. Umm Al-Qura Univ. Med. Sci.-This is an open-access article distributed under the terms and conditions of the-https://creativecommons.org/licenses/by-nc/4.0/-