Umm Al-Qura University

Umm Al-Qura University


- 2016/12/27

Faculty members in the department have set high standards in their researches; they have kept up with the fast-changing developments in biochemistry. Their projects cover metabolism, clinical chemistry, obesity, diabetes mellitus, bone diseases, oncology, molecular biology and environmental chemistry.

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Outlines of Scientific Research:

  1. Oxidative stress & inflammation in chronic diseases.
  2. Biochemical and molecular pathogenesis of Diabetes Mellitus and its complications.
  3. Biochemical and molecular aspects of metabolic disorders.
  4. Molecular and diagnosticapproach of cancer.
  5. Cellular and molecular mechanisms of natural and synthetic products.
  6. Molecular biomarkers as diagnostic, predictive, and risk assessment tool in diseases.
  7. Environmental and nutritional effect in health and diseases.

Publications List:


  1. El-Readi MZ, Eid SY, Al-Amodi HS, Wink M (2016) Fallopia japonica: Bioactive Secondary Metabolites and Molecular Mode of Anticancer. J Tradi Med Clin Natur 5: 193.
  2. Borham, L.E, Mahfoz, A.M., Ibrahim, I.A.A, Shahzad, N., ALrefai, A.A., Labib, A.A., Bin Sef, B., Alshareef, A., Khan, M., Milibary, A., Al Ghamdi, S. The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats. Brain Research, Volume 1648, 1 October 2016, Pages 418-424.
  3.  Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb, Koon-Guan Lee, Kong-Peng Lam, George D.D. Jones, Nickolai A. Barlev and Salvador Macip. BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer Research, September 2016, Volume 76, Issue 18.
  4. Hala Fawzy Mohamed Kamel, and Hiba Saeed Bagader Al-Amodi (2016).Chapter 1: Cancer Biomarkers, Role of Biomarkers in Medicine, Prof. Mu Wang (Ed.), p.1-31, InTech, DOI: 10.5772/62421. Published online: 17. August, 2016.
  5. MH Mukhtar, WA Nasif, AT Babak. Helicobacter Pylori Infection Is Associated with Dyslipidemia and Increased Levels of Oxidized LDL in Type-2 Diabetes Mellitus. Journal of Diabetes Mellitus 6 (03), 12 July 2016, 185.
  6. Silvia Di Giacomo, Antonella Di Sotto, Mahmoud Zaki El-Readi, Gabriela Mazzanti, Michael Wink. α-Hexylcinnamaldehyde Synergistically Increases Doxorubicin Cytotoxicity Towards Human Cancer Cell Lines. Anticancer Research 36 (7), 7 July 2016, 3347-3351.
  7. El-Readi MZ, Eid SY, Wink M. Gene expression profiling by DNA microarrays in colon cancer treated with chelidonine alkaloid BMC Genomics 2016, Volume 17 Suppl 6,  P 133. DOI 10.1186/s12864-016-2858-0
  8. Abeer A. Alrefai, Mona Saleh, Rehab I Yassen, Mahmoud Kamel and Rabab M Habeeb. Association of the endothelial Nitric Oxide Synthase (eNOS) gene G894T polymorphism with hypertension risk and complications. BMC Genomics 2016, 17 (supple6) P:80.
  9. Assiri, A.M.A., Elbanna, K., Al-Thubiani, A.Ramadan, M.F. Cold-pressed oregano (Origanum vulgare) oil: a rich source of bioactive lipids with novel antioxidant and antimicrobial properties. European Food Research and Technology Volume 242, Issue 7, 1 July 2016, Pages 1013-1023.
  10. Nasif, W.A., Mukhtar, M.H.Nour Eldein, M.M.Ashgar, S.S. Oxidative DNA damage and oxidized low density lipoprotein in Type II diabetes mellitus among patients with Helicobacter pylori infection. Diabetology and Metabolic Syndrome, Volume 8, Issue 1, 3 May 2016, Article number 34
  11. Ramadan, M.F.Mohdaly, A.A.A.Assiri, A.M.A.Tadros, M.Niemeyer, B. Functional characteristics, nutritional value and industrial applications of Madhuca longifolia seeds: an overview. Journal of Food Science and Technology, Volume 53, Issue 5, 1 May 2016, Pages 2149-2157.
  12. Fatani, S.H., Saleh, S.A.K., Adly, H.M.Abdulkhaliq, A.A. Trace Element Alterations in the Hair of Diabetic and Obese Women. Biological Trace Element Research, 13 April 2016, Pages 1-8.
  13. Mahmoud, A.A.Ali, A.H.K.Eldin, E.N. Sirtuin 1 gene rs2273773 C > T single nucleotide polymorphism and protein oxidation markers in asthmatic patients. Egyptian Journal of Medical Human Genetics, Volume 17, Issue 2, 1 April 2016, Pages 191-196.
  14. Nabih, E.S.Kamel, H.F.M.Kamel, T.B.  Association between CD14 Polymorphism (−1145G/A) and Childhood Bronchial Asthma. Biochemical Genetics. Volume 54, Issue 1, 1 February 2016, Pages 50-60.
  15. Eldin, E.E.M.N.Elshebiny, H.A.-F.Mostafa Mohamed, T.Abdel-Aziz, M.A.-A.El-Readi, M.Z. The role of antiepileptic drugs in free radicals generation and antioxidant levels in epileptic patients. International Journal of Neuroscience, Volume 126, Issue 2, 1 February 2016, Pages 105-115.
  16. Fatani, S.H.Babakr, A.T.Nour Eldin, E.M.Almarzouki, A.A. Lipid peroxidation is associated with poor control of type-2 diabetes mellitus. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 2016.
  17. Eid, S.Y., El-ReadiM.Z., Wink, M., Myricetin inhibits inflammation with marginal cytotoxicity. Journal of International Society of Antioxidants in Nutrition & Health 1 (1), 2016.
  18. El-Read, M. Z., Eid, S.Y., Wink, M., Antioxidant and cytotoxic activities of the flavonoid rutin. Journal of International Society of Antioxidants in Nutrition & Health 1 (1), 2016
  19. Assiri, A.M.A.Elbanna, K.Abulreesh, H.H.Ramadan, M.F. Bioactive compounds of cold-pressed thyme (Thymus vulgaris) oil with antioxidant and antimicrobial properties. Journal of Oleo Science, Volume 65, Issue 8, 2016, Pages 629-640
  20. Amin, A. Mukhtar, M.NoorEldin, E., Gethami, F.Hafez, F.Fatani, S.Bogari, N.NoorEldin, M.Babakr, A.Khogeer, S.Fawzy, A. Prediction of hepatic fibrosis in patients with chronic hepatitis C genotype 4: A non-invasive biochemical analysis. Biosciences Biotechnology Research Asia, Volume 13, Issue 1, 2016, Pages 287-297
  21. Hala FM Kamel. Response to comment on “Evaluation of diagnostic and predictive value of serum adipokines: Leptin, resistin and visfatin in postmenopausal breast cancer”. Obesity research & clinical practice 10 (1), 1 Jan 2016, 96-97 doi: 10.1016/j.orcp.2016.01.002
  22. Assiri, A.M.A.Kamel, H.F.M. Evaluation of diagnostic and predictive value of serum adipokines: Leptin, resistin and visfatin in postmenopausal breast cancer. Obesity Research and Clinical Practice, 2016. 10(4): p. 442-53
  23. Sameer H Fatani, Mohammed H Mukhtar, Abeer S Ali, Hoda M El-Emshaty, Wesam A Nasif. Correlation between Serum Anti-Apoptotic Bcl-2 Level and its Immunohistochemical Expression in Relation to Apoptosis in Gastric Cancer. Journal of Molecular Biomarkers & Diagnosis 2015, Volume 6, Issue 6, 1000247.
  24. Assiri, A.M.A.El-Baz, H.A.Amin, A.H. Tumor necrosis factor inhibition increases the revascularization of ischemic hind-limbs in diabetic mice. Naunyn-Schmiedeberg's. Archives of Pharmacology, Volume 388, Issue 10, 1 October 2015, Article number 1138, Pages 1053-1060.
  25. El-Naa, M.M.El-Refaei, M.F.Nasif, W.A.El-Brairy, A.I.El-Readi, M.Z. In-vivo antioxidant and anti-inflammatory activity of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists in animal model of bronchial asthma. Journal of Pharmacy and Pharmacology, Volume 67, Issue 10, 1 October 2015, Pages 1421-1430.
  26. Assiri, A.M.A.Kamel, H.F.M.Hassanien, M.F.R. Resistin, visfatin, adiponectin, and leptin: Risk of breast cancer in pre- and postmenopausal saudi females and their possible diagnostic and predictive implications as novel biomarkers. Disease Markers, Volume 2015, 2015, Article number 253519
  27. Hegazy, R.M.Kamel, H.F.M. Evaluation of the patern of organophosphate poisoning, two years analysis, 2009-2011DAMMAM poisoning control centre (PCC), KSA, retrospective cohort community study. International Journal of Pharma and Bio Sciences, Volume 6, Issue 2, 2015, Pages B452-B463.
  28. El-Emshaty, H.M.Nasif, W.A.Mohamed, I.E. Serum cytokine of IL-10 and IL-12 in chronic liver disease: The immune and inflammatory response. Disease Markers, Volume 2015, 2015, Article number 707254.
  29. HFM Kamel, AM Nassir. Conventional and Promising Biomarkers for Prostate Cancer their Clinical Implication and Prospective Role. J Mol Biomark Diagn 7 (262), 2015, 2
  30. Eid, S.Y.El-Readi, M.Z.Ashour, M.L.Wink, M. Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells. Evidence-based Complementary and Alternative Medicine, Volume 2015, 2015, Article number 868424.
  31. Eid, S. , El-Readi, M. , Fatani, S. , Mohamed Nour Eldin, E. and Wink, M. (2015) Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer. Pharmacology & Pharmacy6, 146-176. doi:10.4236/pp.2015.63017
  32. Saleh A.k. Saleh · Adly H.M. · Fatani S. H. · Nassir A. M . Validity of serum Eotaxin-1 in diagnosis of prostate cancer. October 2015 · Clinical Chemistry 10/2015; 61(10S):S109.
  33. Adly HM, Saleh SA, Saati AA, Fatani SH. Assessment of excess cancer risk associated with exposure to some airborne trace elements. October 2015 · Clinical Chemistry 10/2015; 61(10S):S109.
  34. Nour Eldin, E.E.M., Almarzouki, A.Assiri, A.M., Elsheikh, O.M., Mohamed, B.E.A.Babakr, A.T. Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men. Diabetology and Metabolic Syndrome. Volume 6, Issue 1, 30 August 2014, Article number 94.
  35. Ajabnoor, G.M.Bahijri, S.Borai, A., Abdulkhaliq, A.A.Al-Aama, J.Y.Chrousos, G.P. Health impact of fasting in Saudi Arabia during Ramadan: Association with disturbed circadian rhythm and metabolic and sleeping patterns. PLoS ONE, Volume 9, Issue 5, 8 May 2014, Article number e96500.
  36. Alkhotani, A.Eldin, E.E.M.N.Zaghloul, A.Mujahid, S. Evaluation of neonatal jaundice in the Makkah region. Scientific Reports, Volume 4, 25 April 2014, Article number 4802
  37. Ragia M Hegazy, Hala FM Kame. Oxidant Hepatic &/or Haem. Injury on Fuel-Station Workers Exposed to Benzene Vapor, Possible Protection of Antioxidants. American Journal of Medicine and Medical Sciences 4 (2), 2014,35-46
  38. Assiri, A.M.A.Ramadan, M.F.Alshmy, H.Morsel, J.-T. Bioactive compounds and antiradical potential of Campanula medium lipids. Chemistry of Natural Compounds, Volume 50, Issue 6, December 2014, Pages 1088-1091.
  39. Althubiti, M.Lezina, L.Carrera, S., Jukes-Jones, R., Giblett, S.M., Antonov, A., Barlev, N., Saldanha, G.S., Pritchard, C.ACain, K.MacIp, S. Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death and Disease, Volume 5, Issue 11, 1 January 2014, Article number e1528.
  40. Abeer A EL-Refai, Sameer H Fatani, Hala FM Kamel. Association of Adipocytokines: Resistin and Retinol Binding Protein-4 with Severity of Preeclampsia and Insulin Resistance. American Journal of Medical and Biological Research 2 (3), 2014, 76-82
  41. Eid SY, El-Readi MZ, Eldin EE, Fatani SH, Wink M. Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. Phytomedicine. 2013 Dec 15;21(1):47-61. doi: 10.1016/j.phymed.2013.07.019. Epub 2013 Aug 30.
  42. Nasif, W.A.Mukhtar, M.H.El-Emshaty, H.M.AL-Bukhari, T.A. Evaluation of circulating TP53 antigen in the sera of gastric cancer patients: As a tumor marker. Biomarkers and Genomic Medicine, Volume 5, Issue 4, December 2013, Pages 175-180.
  43. Assiri, A.M.A.Hassanien, M.F.R. Bioactive lipids, radical scavenging potential, and antimicrobial properties of cold pressed clove (Syzygium aromaticum) oil. Journal of Medicinal Food, Volume 16, Issue 11, 1 November 2013, Pages 1046-1056.
  44. Ragia M Hegazy, Waleed H Almalki, Eman Farouk, Hala FM Kamel. Assessment of Hepatotoxicity of Obesity in Female Patients’ through Histopathological, Biochemical and Immunohistochemical Study. American Journal of Medicine and Medical Sciences 3 (6), 2013, 126-132
  45. AMA Assiri, HFM Kamel. Correlation of the Leptin-to-Adiponectin Ratio (LAR) with Insulin Resistance in Lean and Obese Saudi Females with Type 2 Diabetes. Life Science Journal 9 (3), 2012.
  46. Manal L. Louka, Enas S. Nabih, Hala F. M. Kamel, Fayda I. Abdel Motaleb, Mohamed A. El Sayed Emerging role of CXCL8 in squamous cell lung carcinoma, ,The Egyptian Journal of Biochemistry and Molecular Biology (2012); December ; 30 (2): 269-328
  47. Ragia M. Hegazy, Raniah Hamdy , Hala F.M. Kamel, Modulation Of IgE Levels In Lead Exposed Children By Parental Cigarette Smoking, Qualyobia Governate, Egypt , Int J Pharm Bio Sci 2011April ; 2(2): (B) 372-385
  48. Nasser A Elhawary , Neveen S. Seif-Eldin , Marwa Zaki,  Saleh A Saleh . Common Tag STSs in the AZF Region Associated with Azoospermia and Severe Oligospermia in Infertile Egyptian Men. July 2010 · Open Andrology Journal 07/2010; 2(1). DOI:10.2174/1876827X01002010011
  49. Assiri, A.M.A., Abdel-Wahab, A.F.I. Evidence of prothrombotic effect of celecoxib and risk of myocardial infarction. Saudi Pharmaceutical Journal, Volume 13, Issue 4, October 2005, Pages 139-147.
  50. Assiri, A.M. Cholinesterase in plasma: Purification and some biochemical properties. Journal of the Chemical Society of Pakistan, Volume 25, Issue 1, 2003, Pages 63-68.
  51. Assiri, A.M.A.Abdel-Wahab, A.F.I. Carnosine protects against doxorubicin-induced cardiotoxicity. Saudi Pharmaceutical Journal, Volume 11, Issue 1-2, January 2003, Pages 23-31.
  52. Khan, I.Assiri, A.M.Hassan, M., Khan, Z.A.Saeed, A. Partial purification of acetylcholinesterase and its inhibition by antibiotics. Journal of the Chemical Society of Pakistan, Volume 24, Issue 3, 2002, Pages 209-214.
  53. Khan, Z.A.Assiri, A.M.Al-Afghani, H.M.A.Maghrabi, T.M.A. Inhibition of oxalate nephrolithiasis with Ammi visnaga (AI-Khillah). International Urology and Nephrology, Volume 33, Issue 4, 2001, Pages 605-608.