Abdullah F. Aldairi^*
Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia
Volume: 10 | Issue: 2 | Pages: 123-132 | December 2024-|-https://doi.org/10.54940/ms55602877-|-PDF
Received:-16/9/2024-|-Received:-2/11/2024-|-Accepted:-10/11/2024
*Corresponding Author: afdairi@uqu.edu.sa

Abstract
Background:-CRC is a common malignancy leading to cause mortality globally. Commiphora gileadensis was used to treat respiratory infections, neuralgic pain, wounds and arthritis.
Methods:-Commiphora gileadensis was harvested; then polysaccharides were extracted. The antiproliferative activity was assessed on two colorectal cancer cell lines; then, an apoptosis assay was conducted to determine cell death. Polysaccharides with antiproliferative effects were digested and separated.
Results:-Commiphora gileadensis separation confirmed the presence polysaccharides that showed anti-proliferative activities on SW480 and SW620 with IC50 13.15 µg/mL and 32.02 µg/mL, respectively. Cell death was activated via apopstosis on SW480, with some resistance on WS620 cell line.
Discussion: The cytotoxic effects of Commiphora gileadensis polysaccharides on SW480 and SW620 were significant as it activated the cellular apoptosis pathway.
Conclusion:-Commiphora gileadensis polysaccharide extracts induce cellular apoptosis on CRC cell line with potent antiproliferative activity.

Keywords
Commiphora gileadensis, colorectal cancer, antiproliferative agent, polysaccharide, natural products.

How to Cite
Aldairi, A. (2024). Activities of Polysaccharides Derived from Commiphora Gileadensis on Colorectal Cancer Cell Lines,-Journal of Umm Al-Qura University for Medical Sciences, 10(2), 123-132.-https://doi.org/10.54940/ms55602877

License
1658-4740/© 2024-by the Authors. Published by-J. Umm Al-Qura Univ. Med. Sci.-This is an open-access article distributed under the terms and conditions of the-https://creativecommons.org/licenses/by-nc/4.0/-