Within the scientific research activities held by the Faculty Members Development Unit on a weekly basis, Dr. Faisal Outaik Al-Malky, Faculty Member at the Department of Pharmaceutical Chemistry, gave a lecture about "the modern ways of constructing Bisbibenzyl compounds" on Thursday 9 November 2017. The study aims to develop new organic construction methods of the Bisbibenzyl compounds that have biological impacts. The study also aims to develop methods to prepare non-organic compounds with the characteristics of Bisbibenzyl compounds.

The derivatives of Bisbibenzyl are known to be characterized by their distinct activity. And based on the importance of these compounds biologically, there was special attention paid to their chemical studies and construction. The constructed compounds were: Recarden D, Recarden C, Polymeratin A, Astralyn A, and Cavlcarin. 

Dr. Faisal Al-Malky conducted this study on several stages. The first project included preparing Recarden D through using the "Wittig" reaction. The upper compound A and C was prepared with SNAr reaction, while the lower compound B and D was prepared through connecting cycle D and B with Suzuki reaction. The compounds were linked with Heck reaction, and the cycle was closed with Wittig reaction, producing the natural product "Recarden D" and reaching the required compound to eliminate the controversy regarding this compound.  

The second project included preparing several organic and non-organic compounds, including Recarden C, and a non-organic compound with the characteristics of the Bisbibenzyl compounds, prepared through connecting cycle A and C with SNAr reaction, and connecting the cycle D and B with Suzuki reaction, both were then connected with Heck reaction, followed by closing the cycle in a new way using the Corey Seebach reaction to produce Recarda C compound. This method helps us reach the compounds of Estralene  A and Kafklaren.

The last project includes preparing the Polymervatin compound through connecting cycle A and cycle C with SNAr reaction, then connecting cycle A and C to B or D, then closing the cycle using Nickel to produce the organic Polymeravatin A compound. Reaching the required compound will make it possible to confirm the data of this compound with the aim of eliminating the controversy about it.

At the end of the lecture, Dr. Faisal answered the questions of faculty members regarding this modern study about organic compounds with effective biological impact.