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Physical Organic and Stereochemistry

CHM3404
Two hours English

Physical Organic and Stereochemistry

Physical Organic and Stereochemistry
1 Introduction, thermodynamic and activation energy. physical and chemical methods for the identification of reaction mechanism
2 Reaction kinetics and mechanism, isotope effect labeling and intermediates determinations
3 Mechanisms of aliphatic nucleophilic substitution reactions, SN1, SN2
4 Mechanisms of addition and elimination reactions, E1, E2
5 Electrophilic addition to carbon-carbon double bond
6 Mechanisms of nucleophilic addition to carbonyl group
7 Mechanisms of radical reactions and photochemistry
8 Solvent effect on chemical reactions
9 The chemistry of the reactive intermediate such as carbanion, carbocation, / carbens and free radicals
10 Introduction to stereochemistry: conformational isomerism, geometrical / isomerism, optical isomerism and Chiral study and their properties
11 Application of stereochemistry in prediction of reaction mechanism
1.1 Mapped to: K1

Recognize and characterize types of reaction mechanism and illustrate principles of molecular rearrangements and structure-reactivity.

Teaching Strategy Lectures
Assessment Methods Final and mid-tern exams.
1.2 Mapped to: K2

Identify methods used for the investigation of reaction mechanisms, energy considerations and stereochemical considerations.

Teaching Strategy Lectures
Assessment Methods Final and mid-term exams.
2.1 Mapped to: S2

Apply reaction mechanisms, stereochemistry, and kinetics in the identification of structures of organic compounds.

Teaching Strategy Lectures and tutorials
Assessment Methods Final , mid-term, and quizzes.
2.2 Mapped to: S3

Compare reactivity based on physical and chemical properties of the molecular structure.

Teaching Strategy Lectures and tutorials
Assessment Methods Final , mid-term, and quizzes.
3.1 Mapped to: V2

Demonstrate learning skills to work as a team in a multidisciplinary environment and demonstrate effective writing, oral communication skills and using ICT tools

Teaching Strategy Web-based study Library visits
Assessment Methods Class and tutorial discussion. Assignment activities, Homework