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Main
UQU Programs
Doctor of Pharmacy

Biopharmaceutics and Basic Pharmacokientics

PHD3316
6 hours English

Biopharmaceutics and Basic Pharmacokientics

Biopharmaceutics and basic PK
PHD3313 Pharmaceutics II
6 hours One requisite
1 Biopharmaceutics and basic pharmacokinetics: Introduction to biopharmaceutical classification system, rates and orders of reactions
2 Gastrointestinal tract – physiological, physicochemical, dosage form and formulation factors
3 Biopharmaceutics and assessments of biopharmaceutical properties
4 Mechanisms of drug absorption through GIT and factors influencing drug absorption though GIT
5 Bioavailability and bioequivalences: Absolute and relative bioavailability
6 Dosage regimens: influence on the plasma concentration time profile of a drug in the body
7 Mathematical fundamentals in pharmacokinetics
8 Volume of drug distribution and plasma protein binding of drugs
9 Drug elimination and clearance: metabolism, renal and non-renal routes of drug excretion
10 Pharmacokinetic models: one-compartment open model, multicompartment models
11 Characterization of drugs’ pharmacokinetics after different routes of drug administration (oral)
12 Characterization of drugs’ pharmacokinetics after different routes of drug administration (IV bolus, IV infusion)
13 Multiple-dosage regimen
14 Nonlinear pharmacokinetic model
15 Physiological pharmacokinetic models: Mean residence time
16 Biopharmaceutics considerations in drug design
17 Impact of drug product quality and biopharmaceutics on clinical efficacy
18 Modified-release drug products
19 Relationship between pharmacokinetics and pharmacodynamics
20 Introduction to biotechnology
21 Biosensors
22 Genetic engineering
23 Principles of fermentation
24 Recombinant DNA Technology (Gene Cloning)
25 Microbial genetics and biotransformation
26 Preparation and delivery of biopharmaceuticals 1
27 Preparation and delivery of biopharmaceuticals 2
28 Preparations and delivery of vaccines
29 Novel drug delivery systems
30 Blood products and plasma substitute
1.1 Mapped to: K1

Demonstrate the factors that influence absorption, distribution, metabolism and excretion (ADME) of drugs in the body.

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
1.2 Mapped to: K3

Demonstrate the knowledge of the influence of biopharmaceutics and pharmacokinetics principles on the drug design, quality and efficacy

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
1.3 Mapped to: K3

Demonstrate knowledge and comprehension of the principles of pharmaceutical biotechnology, including the application of genetic engineering

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
2.1 Mapped to: S1

Explain how dosage forms affect the ADME of drug substances on various parts of the body

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
2.2 Mapped to: S1, S2

Demonstrate basic knowledge of biopharmaceutics and pharmacokinetics using various mathematical models

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
2.3 Mapped to: S2, S3

Demonstrate in-depth knowledge of principles of biotechnology and its clinical application and legalization

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
3.1 Mapped to: V1

Use constructive criticism and instructions during discussion and group work.

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
3.2 Mapped to: V3

Use necessary means to achieve shared goals with a great sense of responsibility, leadership and belonging

Teaching Strategy Lectures Educational application Practice problems
Assessment Methods Written exams In class discussions Journal club Case study Project
Assessment
Weight
Mid-term exam 1
15%
Project
10%
Midyear Exam
25%
Mid-term exam 2
15%
Journal Club Presentation
10%
End of Term 2 Exam
25%
Total
100%