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Main
UQU Programs
Doctor of Pharmacy

Medicinal Chemistry I

PHD3311
Two hours English

Medicinal Chemistry I

Medicinal Chemistry I
CHM3209 Drug Qualitative and Quantitative Analysis
Two hours Two requisites
MED3210 Pharmaceutical Biochemistry
Two hours Two requisites
1 General aspects of medicinal chemistry
2 Physicochemical properties of drug substances
3 Pharmacokinetics and biopharmaceutical properties of drug substances
4 Spatial organization and receptor mapping (protein crystallography)
5 Spatial organization and receptor mapping (pharmacophore identification and Molecular modelling)
6 Lead compound discovery strategies
7 The chemistry of drug action (stereochemistry)
8 The chemistry of drug action (The role of functional groups in drug-receptor interaction)
9 Primary exploration of SAR (Molecular variations in homologous Series)
10 Primary exploration of SAR (Isostere & bioisostere)
11 Primary exploration of SAR (Ring Transformations & Conformation Restriction)
12 Chemical modifications influence pharmacokinetic properties and the development of prodrugs
13 Drug metabolism phase I (oxidative reactions)
14 Drug metabolism phase I (reductive and hydrolytic reactions)
15 Drug metabolism Phase II
16 Peripheral nervous system (PNS) drugs (adrenergic agents)
17 Peripheral nervous system (PNS) drugs (cholinergic, Muscarinic agents)
18 Peripheral nervous system (PNS) drugs (cholinergic, Nicotinic agents)
19 Opioid drugs (SAR of morphine)
20 Opioid drugs (Opioid Antagonists)
21 Opioid drugs (Opioid derivatives)
22 Nonsteroidal anti-inflammatory drugs (NSAIDs)
23 Nonsteroidal anti-inflammatory drugs (COX2 selective inhibitors)
24 Nonsteroidal anti-inflammatory drugs (Analgesic Antipyretics)
25 Sedative hypnotics and anxiolytic (Benzodiazepines and Z drugs)
26 Sedative hypnotics and anxiolytic (Barbiturates and melatonin)
27 Traditional Antiepileptic drugs
28 Newer Antiepileptic drugs
29 Antipsychotic drugs
30 Antidepressant drugs
31 Introduction to medicinal chemistry
32 Application education of physicochemical properties of drug substances
33 Application education of biopharmaceutical and pharmacokinetics properties of drug substances
34 Protein data bank (PDB)
35 Application education of Lead compound discovery strategies
36 Application education of Lead compound discovery strategies
37 The role of functional groups in drug-receptor interaction tutorial
38 Analyze a simple drug molecule
39 Chemical Library design
40 Patent design
41 Introduction to the docking software
42 Step by step docking
43 Result and profiling the data
44 Drug metabolism tutorial
45 Application education of Drug metabolism
46 GPCR in Protein data bank
47 SAR Analysis of adrenergic drugs
48 SAR Analysis of cholinergic drugs
49 Opioid receptor in Protein data bank
50 SAR Analysis of Opioid antagonists
51 SAR Analysis of Opioid derivatives
52 COX enzymes in Protein data bank
53 SAR Analysis of NSAIDs
54 SAR Analysis of COX II inhibitors
55 SAR Analysis of benzodiazepines
56 SAR Analysis of Barbiturates
57 SAR Analysis of traditional Antiepileptic drugs
58 SAR Analysis of newer Antiepileptic drugs
59 SAR Analysis of Antipsychotic drugs
60 SAR Analysis of Antidepressant drugs
1.1 Mapped to: K1

Demonstrate knowledge and principles of biomedical science related to development of medications.

Teaching Strategy Lectures Educational application
Assessment Methods Written exams Educational application
1.2 Mapped to: K3

Demonstrate the knowledge in drug design, development, and manufacturing using various drug classes according to pharmaceutical factors such as biopharmaceutics, pharmacodynamics, pharmacokinetics, bioequivalence, and the structure-activity relationship.

Teaching Strategy Lectures Educational application
Assessment Methods Written exams Educational application
2.1 Mapped to: S2

Evaluate scientific literature, research methods, drug design, monitoring, evaluating, and adjustment of medication therapy plan in health promotion and diseases prevention.

Teaching Strategy Lectures
Assessment Methods Written Exam Educational applications
2.2 Mapped to: S4

Use docking software to integrate knowledge and get in-depth understanding of molecular modelling.

Teaching Strategy Lectures Educational applications
Assessment Methods Educational applications Assignment
2.3 Mapped to: S5

Demonstrate effective communication and positive relation with others and be able to work as an effective member in a healthcare team

Teaching Strategy Educational applications
Assessment Methods Educational applications Assignment
3.1 Mapped to: V2

Demonstrate a self-learning ability and identify suitable learning objectives

Assessment Methods Educational applications Assignment
3.2 Mapped to: V3

Use necessary means to achieve shared goals with a great sense of responsibility and leadership.

Assessment Methods Educational applications Assignment
Assessment
Weight
Midterm I exam
15%
Assignment on docking and molecular modelling
10%
Midyear exam
25%
Midterm II exam
15%
Application education
10%
Final written exam
25%
Total
100%