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20250417892
Main
UQU Programs
Bachelor of Midwifery

Applied Biochemistry

MED1402
Two hours English

Applied Biochemistry

Applied Biochemistry
1 Biochemical Aspects of Carbohydrates ? Types and classifications of Carbohydrates ? Types and importance of monosaccharides, Disaccharides, and polysaccharides ? Lactose intolerance
2 Biochemical Aspects of Lipids ? FA classification (saturation – essentiality classification). ? Medical and nutritional applications: Omega FA – Prostaglandins – eicosanoids. ? Lipoproteins
3 Biochemical Aspects of proteins ? Amino acids Classification ? Peptide bond formation ? Biological Importance of Proteins ? Denaturation of protein
4 Clinical Enzymology, Overview of metabolic pathways, Bioenergetics ? Classification of enzymes and Co-enzymes ? Iso-enzymes ? Clinical application of enzymes ? Concept of metabolism, catabolism ? Anabolic and catabolic pathways
5 Glycolysis, oxidation of other monosaccharides, Fructose intolerance, galactosemia ? Steps and regulation of glycolysis ? Aerobic & Anaerobic glycolysis ? Clinical correlation: Fructose Lactose intolerance, Galactosemia
6 Glycogen metabolism and regulation ? Glycogen synthesis (glycogenesis) ? Glycogen degradation (Glycogenolysis) ? Steps, Key enzyme and regulation ? Glycogen storage diseases
7 Citric acid cycle, respiratory chain ? Amphibolic nature of the cycle Anaplerotic reactions of CAC ? Respiratory chain complexes, Inhibitors of respiratory chain ? Uncouplers: Dinitrophenol, Valinomycin, Thermogenin (Brown adipose Tissue)
8 Gluconeogenesis, Pentose phosphate pathway, Favism ? Substrates: Glycerol, Lactate, Glucogenic amino acids, Odd chain fatty acids ? Significance of PMP shunt in certain tissues ? Favism
9 Storage and mobilization of fat ? Role of bile salts & bile acids, emulsification of fat ? Absorption of lipid, chylomicron ? Sites & synthesis of TAG ? Lipolysis: Steps & key enzyme, regulation of lipolysis
10 Oxidation of fatty acids, Refsum’s disease ? Transport of fatty acids into mitochondria ? ?- Oxidation of fatty acids steps and energetic ? ?- oxidation & ?-oxidation of fatty acids ? Clinical correlation: Refsum’s disease; deficiencies in Carnitine
11 Cholesterol metabolism, Atherosclerosis, Ketone body metabolism, ketoacidosis ? Overview of steps involved in synthesis of cholesterol ? Clinical Aspects: Atherosclerosis ? Ketogenesis, Ketolysis, starvation and ketosis ? Clinical correlation Ketoacidosis
12 Lipoprotein metabolism, Hyperlipoproteinemias ? Classification and functions of lipoproteins and Apoproteins ? Metabolism and degradation of Chylomicrons, VLDL ? Metabolism and uptake of LDL ? HDL metabolism
13 Catabolism of protein, Urea Cycle, ammonia toxicity ? Transamination reactions, mechanism of action ? Urea cycle: steps and regulation ? Transport and excretion of urea ? Clinical correlation: ammonia toxicity
14 Inborn errors of metabolism (IEMs) ? Disorders and effects of IEMs ? Phenylketonuria (PKU) ? Tyrosinemia ? Alkaptonuria
15 Case discussion Presentations, activities
1.1 Mapped to: K1

Differentiate between carbohydrate, lipid, and protein in the way of their digestion, absorption, and transporting in blood.

Teaching Strategy The student will attend: / 1. Regular 4 hours lectures per week on-campus. / 2. Independent study. / a. Introductory lecture gives an overview. / b. Subsequent lectures with general outline. / c. Tutorials review content. / d. Individual tasks.
Assessment Methods Written Exam SBA (Midterm and Final exam): / a. Mid semester exam (Week 6-8): 50 MCQs (25%). / b. Activities and assignment (25%) & continuous assessment (10%). / c. Final exam (Week 16-17): 100 MCQs (40%).
1.2 Mapped to: K1

Define the key reactions in the metabolic pathways and regulatory mechanisms of carbohydrates, lipids, proteins, and their micro-molecules and determine the site of each.

Teaching Strategy Same as above
Assessment Methods Same as prescribed above
1.3 Mapped to: K3

Discuss the related metabolic disorders and their clinical prints on biochemical and molecular basis.

Teaching Strategy Same as above
Assessment Methods Same as prescribed above
2.1 Mapped to: S1

Interpret symptoms, signs, and biochemical laboratory findings of some metabolic disorders.

Teaching Strategy a. Explanations and examples given in lectures with group discussion. / b. Assignment tasks include open ended tasks. Practiced under supervision in tutorials and lab tasks.
Assessment Methods a. Problem solving questions carrying 20% of mark on each exam and Quiz questions. / - Group and individual assignments as continuous assessment.
2.2 Mapped to: S5

The student can work effectively in a group during preparation of assignment and seminars.

Teaching Strategy Same as prescribed above
Assessment Methods Same as prescribed above
2.3 Mapped to: S2

To develop scientific search skills and writing of a scientific medical subject.

Teaching Strategy Same as prescribed above
Assessment Methods Same as prescribed above
3.1 Mapped to: V1

Demonstrate professionalism and high ethical standards in all aspects of Nursing Medical practice specifically competence, honesty, integrity, compassion, and respect for others.

Teaching Strategy Implemented as follow: Provide guided practice, monitor performance and provide feedback after each step. Inform students about clinical metabolic disorders.
Assessment Methods Clinical case presentation and discussion through the semester using previous medical case histories and presentations.
3.2 Mapped to: V1

Apply Biochemistry Knowledge in different clinical Setting of self learning.

Teaching Strategy Same as prescribed above
Assessment Methods Same as prescribed above
Assessment
Weight
Semester Midterm exam (MCQs) on studied topics (On site / On campus)
25%
Activities Evaluation (continuous assessments)
10%
Case discussion and presentation
25%
Final year exam. 120 minutes multiple choice test (80 MCQs) on studied topics (On site / On campus)
40%
Total
100%